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ea0081p264 | Adrenal and Cardiovascular Endocrinology | ECE2022

Mitotane side effects in the treatment of patients with adrenocortical carcinoma - a retrospective study

Barac Nekic Anja , Zibar Tomšić Karin , Sambula Lana , Matas Nino , Jambrović Martina , Petrak Iva , Dusek Tina , Kastelan Darko

Introduction: Mitotane is widely used to treat adrenocortical carcinoma (ACC) and remains the mainstay of treatment along with surgery. The aim of this study is to evaluate the adverse side effects of mitotane treatment.Materials and Methods: This retrospective study included 36 patients with ACC, ENSAT stage I- IV, who were treated with mitotane in an adjuvant or palliative setting. Patients with ENSAT stage IV who died within 6 months after surgery wer...

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ea0099ep195 | Adrenal and Cardiovascular Endocrinology | ECE2024

Are comorbidities of patients with adrenal incidentaloma tied to sex? Results from a multicenter longitudinal study

Puglisi Soraya , Barac Nekic Anja , Morelli Valentina , Alessi Ylenia , Fosci Michele , Pani Angelo , Zibar Tomšić Karin , palmieri serena , Ferrau Francesco , Pia Anna , Reimondo Giuseppe , Chiodini Iacopo , Kastelan Darko , Terzolo Massimo

Background: A recent cross-sectional study showed that both comorbidities and mortality in patients with adrenal incidentaloma (AI) are tied to sex. However, only few longitudinal studies evaluating the development of arterial hypertension, hyperglycemia, dyslipidemia and bone impairment in patients with AI are available. The aim of this study is to analyze the impact of sex in the development of these comorbidities during long-term follow-up.Patients an...

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Endocrine Abstracts

Mitotane side effects in the treatment of patients with adrenocortical carcinoma - a retrospective study

Are comorbidities of patients with adrenal incidentaloma tied to sex? Results from a multicenter longitudinal study

BiosciAbstracts